Tutkimukset
POLYFENOLIT
Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H, Poutanen K. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 2010Mar 31;11(4):1365-402.
Serrano J, Puupponen-Pimiä R, Dauer A, Aura AM, Saura-Calixto F. Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S310-29. Review.
Bakkalbasi E, Mentes O, Artik N. Food ellagitannins- occurrence, effects of processing and storage. Crit Rev Food Sci Nutr. 2009 Mar;49(3):283-98.
Nurmi T, Mursu J, Heinonen M, Nurmi A, Hiltunen R, Voutilainen S. Metabolism of Berry Anthocyanins to Phenolic Acids in Humans J. Agric. Food Chem. 2009, 57, 2274–2281 Tiivistelmä
Toivanen M, Ryynänen A, Huttunen S, Duricova J, Riihinen K, Törrönen R, Lapinjoki S, Tikkanen-Kaukanen C. Binding of Neisseria meningitidis Pili to Berry Polyphenolic Fractions. J Agric Food Chem 2009:5; 3120–3127. Tiivistelmä
Hellström K, Törrönen R, Mattila P. Proanthocyanidins in common food products of plant origin. J Agric Food Chem 2009: 57; 7899-790. Tiivistelmä
Salminen, H. 2009. Effect of phenolic-rich plant materials on protein and lipid oxidation reactions. Väitöskirja. EKT-sarja 1444. Helsingin yliopisto. Soveltavan kemian ja mikrobiologian laitos. Tiivistelmä
Ovaskainen ML, Törrönen R, Koponen JM, Sinkko H, Hellström J, Reinivuo H, Mattila P. Dietary intake and major food sources of polyphenols in Finnish adults. J Nutr. 2008 Mar;138(3):562-6.
Riihinen, K., Jaakola, L., Kärenlampi, S. ja Hohtola, A. Organ-specific distribution of
Phenolic compounds in bilberry (Vaccinium myrtillus) and ´northblue´ blueberry (Vaccinium
corymbosum x V. angustifolium). Food Chem. 2008;110:156-160. Tiivistelmä
Yue X ja Xu Z. Changes of anthocyanins, anthocyanidins and antioxidant activity in bilberry extract during dry heating. J Food Sci. 2008;73: 494-499. Tiivistelmä
Alakomi HL, Puupponen-Pimiä R, Aura AM, Helander IM, Nohynek L, Oksman-Caldentey KM, Saarela M. Weakening of salmonella with selected microbial metabolites of berry-derived phenolic compounds and organic acids. J Agric Food Chem. 2007;16;55(10):3905-12.
Heinonen M. Antioxidant activity and antimicrobial effect of berry phenolics – a Finnish perspective. Review. Mol. Nutr. Food Res. 2007;51: 684-691.Review. Tiivistelmä
Koponen JM, Happonen AM, Mattila PH, Törrönen AR. Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J Agric Food Chem. 2007 Feb 21;55(4):1612-9.
Wu QK, Koponen JM, Mykkänen HM, Törrönen AR. Berry phenolic extracts modulate the expression of p21(WAF1) and Bax but not Bcl-2 in HT-29 colon cancer cells. J Agric Food Chem. 2007 Feb 21;55(4):1156-63.
Erlund I, Freese R, Marniemi J, Hakala P, Alfthan G. Bioavailability of quercetin from berries and the diet. Nutr Cancer. 2006;54(1):13-7. Tiivistelmä
Mattila P, Hellström J, Törrönen R. Phenolic acids in berries, fruits, and beverages. J Agric Food Chem. 2006 Sep 20;54(19):7193-9.
Nohynek LJ, Alakomi HL, Kähkönen MP, Heinonen M, Helander IM, Oksman-Caldentey KM, Puupponen-Pimiä RH. Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutr Cancer. 2006;54(1):18-32.
Päivärinta E, Pajari AM, Törrönen R, Mutanen M. Ellagic acid and natural sources of ellagitannins as possible chemopreventive agents against intestinal tumorigenesis in the Min mouse. Nutr Cancer. 2006;54(1):79-83.
J.-M. Pihlava, MTT Agrifood Research Finland. Lignans in Foods as Health Promoting
Compounds. Food choices and healthy eating. International Conference September 2nd-3rd 2005, Kauhajoki, Finland. Tiivistelmä
Määttä-Riihinen KR, Kähkönen MP, Törrönen AR, Heinonen IM. Catechins and procyanidins in berries of vaccinium species and their antioxidant activity. J Agric Food Chem. 2005 Nov 2;53(22):8485-91.
Puupponen-Pimiä R, Nohynek L. Alakomi H-L ja Oksman-Caldentey K-M. 2005. The action of berry phenolics against human intestinal pathogens. BioFactors 23: 243–251. Review. Tiivistelmä
Puupponen-Pimiä R, Nohynek L, Hartmann-Schmidlin S, Kähkönen M, Heinonen M, Määttä-Riihinen K ja Oksman-Caldentey K.-M. 2005. Berry phenolics selectively inhibit the growth of intestinal pathogens. J. Appl. Microb. 98: 991–1000. Tiivistelmä
Puupponen-Pimiä R, Nohynek L, Alakomi HL, Oksman-Caldentey KM. Bioactive berry compounds-novel tools against human pathogens. Appl Microbiol Biotechnol. 2005 Apr;67(1):8-18. Epub 2004 Dec 2. Review.
Riihinen K. 2005. Phenolic compounds in Berries. Kuopio University Publications C.
Natural and Environmetal Sciences 187. Academic Dissertation. 97 p.
Viljanen K. 2005. Protein oxidation and protein-lipid interactions in different food models in the presence of berry phenolics". University of Helsinki Department of Applied Chemistry and Michrobiology. Academic Dissertation. 88 p.
http://ethesis.helsinki.fi/julkaisut/maa/skemi/vk/viljanen/proteino.pdf
Aura A-M, Martin-Lopez P, O'Leary K, Williamson G, Oksman-Caldentey K-M, Poutanen K, Saltos-Buelga C. In vitro metabolism of anthocyanins by human gut microflora. Eur J Nutr (2004)
Määtta-Riihinen KR, Kamal-Eldin A, Törrönen AR. Identification and quantification of phenolic compounds in berries of fragaria and rubus species (family rosaceae).
J Agric Food Chem. 2004 ;52:6178-6187.
Määttä-Riihinen K, Kamal-Eldin A, Mattila P, Gonzáles-Paramás, Törrönen R. Distribution and contents of phenolic compounds in eighteen scandinavian berry species. J Agric Food Chem 2004; 52: 4477-4486.
Mertens-Talcott S, Percival S. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett. 2005 Feb 10;218(2):141-51.
Puupponen-Pimiä R, Aura, A-M, Karppinen S, Oksman-Caldentey K-M, Poutanen K. Interactions between plant bioactive food ingredients and intestinal flora - effects on human health. Bioscience Microflora 2004; 2: 67 - 80.
Puupponen-Pimiä R, Nohynek L, Kähkönen M, Heinonen M, Oksman-Caldentey K-M. Effect of berry phenolics on gastrointestinal microbes. XXII Int. Conf. Polyphenols. Helsinki, Finland, 25 - 28 Aug. 2004. - Polyphenols Communications 2004. Hoikkala A, Soidinsalo O (Toim.) Helsingin yliopisto, Organic Chemistry Laboratory 2004.
Rimando A, Kalt W, Magee J, Dewey J, Ballington J. Resveratrol, pterostilbene and piceatannol in vaccinium berries. J Agric Food Chem 2004; 52: 4713-4719.
Viljanen K, Kivikari R, Heinonen M. Protein lipid interactions during liposome oxidation with added anthocyanin and other phenolic compounds. J Agric Food Chem 2004;52:1104-1111.
Törrönen R, Riihinen K. Marjat arvokkaita polyfenolien lähteitä. Kehittyvä elintarvike 2004; 4:12-13.
Erlund I, Marniemi J, Hakala P, Alfthan G, Meririnne E. Ja Aro A. 2003. Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations. Eur. J. Clin. Nutr. 57: 37−42 Tiivistelmä
Määttä K, Kamal-Eldin A, Törrönen R. High-performance liquid chromatography (HPLC) Analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: Ribes species. J Agric Food Chem 2003; 51: 6736-6744.
Zheng W, Wang S. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries and lingonberries. J Agric Food Chem 2003; 51: 502-509.
Duthie G, Gardner P, Kyle J. Plant polyphenols: are they the new magic bullet? Proc Nutr Soc 2003; 62: 599-603.
Erlund I, Marniemi J, Hakala P, Alftan G, Meririnne E, Aro A. Consumption of black currants, lingonberries and bilberries increases serum quersetin concentrations. Eur J Clin Nutr 2003;57:37-42.
Heinonen M. Marjojen antosyaanit antavat väriä ja säilyvyyttä ruokiin. Kehittyvä elintarvike 2003;14 (5):32-33.
Katsube N, Iwashita K, Tsushida T, Yamaki K, Kobori M. Induction of Apoptosis in Cancer Cells by Bilberry (Vaccinium myrtillus) and the Anthocyanins. J Agric Food Chem 2003; 51: 68-75.
Kähkönen M, Heinämäki J, Ollilainen V, Heinonen M. Berry anthocyanins: isolation, identification and antioxidant activities. J Sci Food Agric 2003;83:1403-1411.
Liu R. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003; 78(suppl): 517S–20S.
Lyons M, Chongwoo Y, Toma R, Cho S, Reiboldt W, Lee J, van Breemen R. Resveratrol in raw and baked blueberries and bilberries. J Agri. Food Chem 2003; 51: 5867-5870.
Prior R. Fruits and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr 2003; 78(suppl): 570S–578S.
Puupponen-Pimiä R. Kasvisten terveysvaikutuksia arvioidaan uusilla menetelmillä. Kehittyvä Elintarvike. Vol. 14 ( 2003) No: 5, 38 - 39
Rösch D, Bergmann M, Knorr D, Kroh L. Structure-antioxidant efficiency relationships of phenolic compounds and their contribution to the antioxidant activity of sea buckthorn juice. J Agric Food Chem 2003; 51: 4233-4239
Aura A-M, O'Leary KA, Williamson G, Ojala M, Bailey M, Puupponen-Pimiä R, Nuutila AM, Oksman-Caldentey, K-M, Poutanen K. Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro. Journal of Agricultural and Food Chemistry . Vol. 50 (2002) No: 6, 1725 - 1730.
Eiro M, Heinonen M. Anthocyanin color behavior and stability during storage: effect of intermolecular copigmentation. J Agric Food Chem 2002;50:7461-7466.
Erlund I, Silaste M, Alfthan G, Rantala M, Kesaniemi Y, Aro A. Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables. Eur J Clin Nutr 2002;56:891-898.
Erlund I. Chemical Analysis and Pharmacokinetics of the Flavonoids Quercetin, Hesperetin and Naringenin in Humans. Väitöskirja. Kansanterveyslaitoksen julkaisuja A27. Helsingin yliopisto 2002.
Frank J, Kamal-Eldin A, Lundh T, Määttä K, Törrönen R, Vessby B. Effects of dietary anthocyanins on tocopherols and lipids in rats. J Agric Food Chem. 2002 Dec 4;50(25):7226-30. Erratum in: J Agric Food Chem. 2003 May 7;51(10):3196.
Jaakola L, Määttä K, Pirttilä AM, Törrönen R, Kärenlampi S, Hohtola A. Expression of genes involved in anthocyanin biosynthesis in relation to anthocyanin, proanthocyanidin, and flavonol levels during bilberry fruit development. Plant Physiol 2002; 130: 729-739.
Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, Hakulinen T, Aromaa A. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002;76: 560-568.
Saarinen N, Smeds A, Mäkelä S, Ämmälä J, Hakala K, Pihlava J-M, Ryhänen E-L, Sjöholm R, Santti R. Structural determinants of plant lignans for the formation of enterolactone in vivo. J Chromatog 2002; B 777: 311-319.
Hirvonen T, Virtamo J, Korhonen P, Albanes D, Pietinen P: Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control 2001;12:789-798.
Hirvonen T, Pietinen P, Virtanen M, Ovaskainen ML, Häkkinen S, Albanes D, Virtamo J. Intake of flavonols and flavones and risk of coronary heart disease in male smokers. Epidemiology 2001;12:62-67.
Hirvonen T. Flavonol and flavone intake and risk of cardiovascular disease and cancer in male smokers. Väitöskirja. Kansanterveyslaitoksen julkaisuja A19. Helsinki 2001.
Hyvärinen H, Taipale M. 2001. Lignaanien terveysvaikutuksia. In: Hyvärinen, Helena (toim.) . Kasviperäiset biomolekyylit - fenoliset yhdisteet ja terpeenit : Kirjallisuuskatsaus. MTT:n julkaisuja. Sarja A 100: 52-58. http://www.mtt.fi/asarja/pdf/asarja100.pdf
Keskitalo M., Hyvärinen H, Pihlava J. 2001. Yleistä fenolisista yhdisteistä. In: Hyvärinen, Helena (toim.). Kasviperäiset biomolekyylit - fenoliset yhdisteet ja terpeenit : Kirjallisuuskatsaus. MTT:n julkaisuja. Sarja A 100: 9-13. http://www.mtt.fi/asarja/pdf/asarja100.pdf
Kähkönen M, Hopia A, Heinonen M. Berry phenolics and their antioxidant activity. J Agric Food Chem 2001;49:4076-4082.
Määttä K, Kamal-Eldin A, Törrönen R. Phenolic compounds in berries of black, red, green, and white currants (Ribes sp.). Antioxid Redox Signal 2001; 3: 981-993.
Kumpulainen J. 2001. Flavonoidit. Teoksessa: Jorma Kumpulainen (toim.). Suomalaisten elintarvikkeiden ravitsemuksellinen laatu ja kemiallinen turvallisuus. 17-20. (Julkaisu myös englanninkielisenä: Flavonoids.Selected nutrients, natural antioxidants and chemical contaminants in Finnish food. Jorma Kumpulainen (Ed.).
Kumpulainen J. 2001. Intakes of flavonoids, phenolic acids and lignans in various populations. Teoksessa: Sari Voutilainen & Jukka T. Salonen (Toim.).Third International Conference on Natural Antioxidants and Anticarcinogens In Food, Health and Disease (NAHD 2001), June 6-9, 2001 Helsinki, Abstracts. Kuopion yliopiston julkaisuja D. Lääketiede 246: 24.
Mattila P, Kumpulainen J. 2001. Flavonoidien ja fenolisten happojen terveysvaikutukset. Teoksessa: Hyvärinen H (toim.). Kasviperäiset biomolekyylit - fenoliset yhdisteet ja terpeenit : Kirjallisuuskatsaus. MTT:n julkaisuja. Sarja A 100: 45-51. http://www.mtt.fi/asarja/pdf/asarja100.pdf
Nyman N, Kumpulainen J. Determination of anthocyanidins in berries and red wine by high-performance liquid chromatography. J Agric Food Chem 2001; 49: 4183-4187.
Nyman N, Kumpulainen J. 2001. HPLC analysis of anthocyanidins in berries and red wine. Teoksessa : Voutilainen S, Salonen JT (Toim.). Third International Conference on Natural Antioxidants and Anticarcinogens In Food, Health and Disease (NAHD 2001), June 6-9, 2001 Helsinki, Abstracts. Kuopion yliopiston julkaisuja D. Lääketiede 246: 78.
Nyman N. Kumpulainen J. 2001. The anthocyanidin content of some fruits, berries and wines. Teoksessa: Voutilainen S, Salonen JT (Toim.). Third International Conference on Natural Antioxidants and Anticarcinogens In Food, Health and Disease (NAHD 2001), June 6-9, 2001 Helsinki, Abstracts. Kuopion yliopiston julkaisuja D. Lääketiede 246: 1.
Puupponen-Pimiä R, Nohynek L, Meier C, Kähkönen M, Heinonen M, Hopia A, Oksman-Caldentey KM. Antimicrobial properties of phenolic compounds from berries. J Appl Microb 2001;90:494-507. Tiivistelmä
Puupponen-Pimiä R, Nohynek L, Kähkönen M, Heinonen M, Oksman-Caldentey K-M. Finnish berries are potential inhibitors of gram-negative bacteria. - Final COST 916 Conf. Bioactive compounds in plant foods. Tenerife, 26 - 28 April 2001. (2001), s. 149
Puupponen-Pimiä R, Nohynek L, Kähkönen M, Heinonen M, Oksman-Caldentey K-M. Finnish berries are potential inhibitors of intestinal pathogens. International Congress on Food Safety and Toxicology. Kuopio, 24 - 25 Aug. 2001. – Kuopion yliopiston julkaisuja D. Lääketiede 249. Kuopion yliopisto 2001.
Rauha J. The search for biological activity in Finnish plant extracts containing phenolic compounds. Academic dissertation 2001.
Törrönen R, Puupponen-Pimiä R. Kotimaiset marjat terveysvaikutteisten yhdisteiden lähteenä. Kemia-Kemi 2001; 28: 609-612.
Clifford M, Schalbert A. Ellagitannins – nature, occurrence and dietary burden. Review. J Sci Food Agric 2000; 80: 1118-1125.
Häkkinen SH, Törrönen AR. Content of flavonols and selected phenolic acids in strawberries and Vaccinium species: influence of cultivar, cultivation site and technique. Food Res Int 2000; 33: 517–524.
Häkkinen SH, Kärenlampi SO, Mykkänen HM, Törrönen AR. Influence of domestic processing and storage on flavonol contents in berries. J Agric Food Chem 2000; 48: 2960–2965. Tiivistelmä
Häkkinen SH, Kärenlampi SO, Mykkänen HM, Heinonen IM, Törrönen AR. Ellagic acid content in berries: Influence of domestic processing and storage. Eur Food Res Technol 2000; 212: 75–80.
Häkkinen S. Flavonols and phenolic acids in berries and berry products. Väitöskirja. Kuopion yliopiston julkaisuja D. Lääketiede 221. Kuopio 2000.
Mazur W, Uehara M, Wähälä K, Adlercreutz H. Phyto-oestrogen content of berries and plasma consentrations and urinary excretion of enterolactone after a single strawberry-meal in human subjects. Br J Nutr 2000;83:381-387.
Rauha J, Remes S, Heinonen M, Hopia A, Kähkönen M, Kujala T, Pihlaja K, Vuorela H, Vuorela P. Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Int J Food Microbiol. 2000; 25;56(1):3-12.
Vuorinen H, Määttä K, Törrönen R. Content of the flavonols myricetin, quercetin, and kaempferol in Finnish berry wines. J Agric Food Chem 2000;48:2675–2680. Tiivistelmä
Häkkinen SH, Kärenlampi SO, Heinonen IM, Mykkänen HM, Törrönen AR. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem 1999; 47: 2274–2279. Tiivistelmä
Häkkinen S, Heinonen M, Kärenlampi S, Mykkänen H, Ruuskanen J, Törrönen R. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res Int 1999; 32: 345–353. Tiivistelmä
Häkkinen SH, Kärenlampi SO, Heinonen IM, Mykkänen HM, Törrönen AR. HPLC method for screening of flavonoids and phenolic acids in berries. J Sci Food Agric 1998; 77: 543-551.
Heinonen M, Meyer A, Frankel E. Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation. J Agric Food Chem 1998; 46: 4107-4112.
Häkkinen S, Auriola S. High-performance liquid chromatography with electrospray ionisation mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries. J Chromatogr A 1998; 829: 91–100.
Prior R, Cao G, Martin A, Sofic E, McEwen J, O'Brien C, Lischner N, Ehlenfeldt M, Kalt W, Krewer G, Mainland CM. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J Agric Food Chem 1998; 46: 2686-2693.
Satué-Gracia M, Heinonen M, Frankel E. Anthocyanins as antioxidants on human low-density lipoprotein and lecithin-liposome systems. J Agric Food Chem 1997; 45:3362-3367.
Wang, H, Cao G, Prior R. Oxygen radical absorbing capacity of antocyanins. J Agric Food Chem 1997; 45: 304-309.